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Under a Creative Commons license Open access To report our experience with targeted-ultrasound in assessing 142 cases with clustered microcalcifications of intermediate concern detected on digital mammography. All cases had histopathologically-proven microcalcifications within the biopsied or surgical specimens. There were 30%[43/142] breast cancers and 70%[99/142] benign lesions. Only 26%[37/142] of clustered microcalcifications were identified on targeted-ultrasound and other
findings including negative study (n = 33), anechoic ducts or cysts (n = 70), dilated ducts with echogenic content (n = 13) and hypoechoic nodules (n = 26). There was no statistical difference of the frequency of negative ultrasound between benign and malignant microcalcifications (P = 0.071). However, only 7.1%[5/70] cases with anechoic ducts or cysts were proven to be breast cancer. The
frequencies of depiction of dilated ducts with echogenic foci or hypoechoic nodules were significantly higher for malignant microcalcifications (P < 0.001). Ultrasound was significantly more sensitive for the identification of malignant cases but biopsy of clustered microcalcifications is still warranted when targeted-ultrasound revealed negative findings. Digital
mammography Microcalcifications Cluster Microcalcifications Amorphous Coarse heterogeneous Ultrasound Cited by (0)Copyright © 2011 Elsevier Ltd. All rights reserved. OverviewWhat are breast calcifications?Breast calcifications are calcium deposits that commonly develop in breast tissue. They’re painless and too tiny to feel with your fingers, so you likely won’t know you have them unless they appear on a mammogram. A mammogram is a low-dose X-ray that detects atypical growths in breast tissue. While calcifications are usually harmless, they can be an early sign of abnormal cells developing in your breast tissue. The size, shape and distribution of the calcifications may provide clues as to whether they’re a marker of a benign (noncancerous) condition or if more testing is needed to rule out malignancy (cancer). What are the different types of breast calcifications?There are two types of breast calcifications. They appear differently on a mammogram.
How common are breast calcifications?Breast calcifications are very common, especially if you’re over 50. About half of people assigned female at birth get benign breast calcifications. Symptoms and CausesWhat are the symptoms of breast calcification?Breast calcifications often don’t cause symptoms, and they’re too small to feel during a breast exam. Instead, you’ll likely learn that you have them during a routine mammogram. What causes breast calcifications?Researchers don’t know what causes calcifications, but several possible explanations exist. Calcium deposits form in response to various processes affecting your breast tissue. Benign breast calcifications are associated with:
Cancerous breast calcifications are often related to ductal carcinoma in situ (DCIS). DCIS is a non-invasive form of breast cancer that forms in your milk ducts. Non-invasive means that cancer hasn’t spread beyond your milk ducts. What doesn’t cause breast calcifications?The name can be confusing, but you can’t get breast calcifications by having too much calcium in your diet or taking too many calcium supplements. Diagnosis and TestsHow are breast calcifications diagnosed?Most breast calcifications are benign and don’t require any special follow up. There is overlap, though, between the commonly benign calcifications and calcifications that could be an indication of something abnormal. In other words, they can often look the same on your mammogram. For instance, if the mammogram shows a tight cluster of calcifications or tiny flecks of white in a line, the radiologist (the specialist who analyzes the X-ray) may recommend additional testing to rule out cancer. Follow-up tests may include:
Can a mammogram be incorrect in identifying breast calcifications?Sometimes noncancerous lumps or cysts can be associated with calcifications on a mammogram. So can powders, creams or deodorants applied on the skin near your breasts. This is why you shouldn’t wear deodorant to a mammogram. If you forget, be sure to wipe it off before the test begins. Management and TreatmentHow are breast calcifications treated?Most causes of breast calcification are benign (not cancerous) and don’t require treatment. The radiologist who reviews your X-rays for future mammograms can compare new images to previous ones and see if the calcifications have changed. If one or more follow-up tests indicate that the calcifications are abnormal or may be signs of cancer, you may need to see a doctor who specializes in breast diseases. Most commonly, this is a breast surgeon. Treatment options may include:
Discuss your results and treatment options with your healthcare provider. Do breast calcifications need to be removed?Not usually. Calcium deposits form when cells divide and grow. They’re harmless on their own. The only time to be concerned is if the calcifications result from cells growing and dividing abnormally, as with precancerous cells or cancer. Even then, the cancer cells — not the calcifications — would need to be removed. PreventionHow can I prevent breast calcifications?You can’t prevent breast calcifications, but early detection through a mammogram is important in identifying any possible cancer that could develop. Outlook / PrognosisCan breast calcifications turn into cancer?Microcalcifications are sometimes — not always — a sign of cancer in your breasts. But usually, calcifications are a sign of a benign condition. The good news is that once a mammogram detects calcifications, they become part of your medical record. The radiologist who reviews future X-rays can note any differences that may indicate precancerous changes so that you can receive further testing and treatment as needed. Early detection can prevent breast cancer. What percentage of breast calcifications are cancerous?According to one study, suspicious calcifications that require follow-up testing turn out to be cancer approximately 12% to 40% of the time. Other research suggests that many of these cases are likely false positives, where a possible or questioned cancer diagnosis turns out to be benign. Research is ongoing to improve cancer detection technologies so that misdiagnosis doesn’t happen. Routine mammograms are essential for detecting cancer early. Microcalcifications are present in approximately half of breast cancer cases with no detectible lump. Mammography screening that detects microcalcifications aids in diagnosing 85% to 95% of DCIS, or the early cancer cells that are contained within the milk ducts. Living WithShould I worry about calcifications in my breast?Calcifications are usually benign and not cause for concern. In the rare instance when they may be a marker for cancer, your provider can intervene as needed to get you closer to a diagnosis and the early-stage treatment you need. What do I need to do if breast calcifications are found during a future mammogram?Continue getting routine mammograms and discuss any concerns about breast calcifications with your provider. Generally, if you’re at average risk of breast cancer, you should begin routine screenings for breast cancer every one or two years, starting at age 40. If your calcifications are potentially cancer-related, you may need additional imaging procedures or more frequent mammograms. Follow your provider’s guidance on the most appropriate mammogram follow-up for you. What questions should I ask my doctor?
A note from Cleveland Clinic Even a slight chance that calcifications may be a marker for cancer can cause some people to assume the worst. But try not to jump to conclusions if your provider finds calcifications on a mammogram. Many benign conditions can leave behind calcium deposits in your breast tissue. These traces aren't likely a sign of malignancy. If cancer is found to be the cause, discuss your prognosis with your provider. There may be treatments available that can prevent your cancer from progressing or that can cure it completely. How often are grouped calcifications cancerous?Combining the clinical features and distribution features of calcifications, the malignancy rate of grouped amorphous calcifications found by screening mammograms was 7.8% (95% CI: 5.8%, 10.4%) less than 10%.
Can clustered microcalcifications be benign?Although breast calcifications are usually noncancerous (benign), certain patterns of calcifications — such as tight clusters with irregular shapes and fine appearance — may indicate breast cancer or precancerous changes to breast tissue.
What are the odds of breast calcifications being cancerous?The study notes that calcifications are the only sign of breast cancer in 12.7 to 41.2 percent of women who undergo further testing after their mammogram. Researchers found that 54.5 percent of calcifications that are associated with cancer could have been potentially diagnosed earlier.
What stage cancer are microcalcifications?“The most common form of cancer we see with calcifications is ductal carcinoma in situ, which is considered stage 0 cancer,” Dryden says.
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What percentage of clustered microcalcifications are cancerous
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