Can you take advil and allergy medicine at the same time

Reactions to aspirin are common. If you have an aspirin allergy or sensitivity, you may also have a reaction to nonsteroidal anti-inflammatory drugs (NSAIDs), including ibuprofen (Advil, Motrin IB, others) and naproxen sodium (Aleve).

Aspirin allergy symptoms

An aspirin allergy or sensitivity, or a reaction to NSAIDs, can cause symptoms that range from mild to severe. Reactions occur within minutes to hours of taking the medication. They may include:

  • Hives
  • Itchy skin
  • Runny nose
  • Red eyes
  • Swelling of the lips, tongue or face
  • Coughing, wheezing or shortness of breath
  • Anaphylaxis — a rare, life-threatening allergic reaction

If you have asthma, nasal polyps, chronic sinusitis or chronic hives (urticaria), you're more likely to have a reaction to aspirin or NSAIDs. When a reaction occurs, it can worsen symptoms of these conditions.

What you can do

Having asthma or another of these conditions doesn't guarantee you'll have a reaction, or that you should avoid aspirin and other NSAIDs. However, if you've ever had a severe reaction to an NSAID or you're uncertain about your reaction, it's best to avoid all NSAIDs until you've had an evaluation by your doctor — whether you have one of these conditions or not.

Keep in mind that aspirin and other NSAIDs are found in many over-the-counter medications — so check labels carefully. If you aren't sure if your medication contains an NSAID, ask your doctor or pharmacist. It may be OK for you to use acetaminophen (Tylenol, others) instead, but check with your doctor first to make sure it's safe for you.

Always tell your doctor if you have any medication reaction, particularly if it's severe. For a serious reaction, you may need to see a doctor who specializes in diagnosing and treating this type of reaction (allergist/immunologist).

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March 05, 2022

  1. Is it possible to be allergic to aspirin? American Academy of Allergy, Asthma and Immunology. https://www.aaaai.org/conditions-and-treatments/library/allergy-library/aspirin-allergy. Accessed April 9, 2020.
  2. Simon RA. NSAIDs (including aspirin): Allergic and pseudoallergic reactions. https://www.uptodate.com/contents/search. Accessed April 9, 2020.
  3. Burks AW, et al. Hypersensitivity to aspirin and other nonsteroidal antiinflammatory drugs. In: Middleton's Allergy: Principles and Practice. 9th ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed April 9, 2020.

See more Expert Answers

See also

  1. Allergies
  2. Allergy medications: Know your options
  3. Allergy-proof your home
  4. Anaphylaxis
  5. Anaphylaxis: First aid
  6. Avoid rebound nasal congestion
  7. Diarrhea
  8. Dizziness
  9. Does honey offer sweet relief for allergies?
  10. Drug allergy
  11. Drug desensitization
  12. Hives and angioedema
  13. Nasal Cleaning
  14. Nasal spray addiction: Is it real?
  15. Nausea and vomiting
  16. Prednisone risks, benefits
  17. Prednisone withdrawal: Why taper down slowly?
  18. Shock
  19. Shortness of breath
  20. Common skin rashes
  21. Sulfa allergy
  22. Tachycardia
  23. Allergy tests

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Can you take advil and allergy medicine at the same time


In a previous blog (A Parent’s Guide to Over-the-Counter Medications), parents were given some important tips to help them safely navigate their way through the children’s pharmacy aisle.  However, deciding between over-the-counter (OTC) brands and medications can sometimes be confusing and overwhelming. Today, let’s go through some of the most common fever, allergy and cold/cough medications available:

Fever and Pain: 

Fever and pain in children can be safely treated with 2 medications, acetaminophen and ibuprofen. As shown in the table, each of these generic medications is marketed and sold under several, different brand names.

OVER-THE-COUNTER FEVER AND PAIN MEDICATIONS:

ACTIVE INGREDIENT

BRAND NAME

EXTRA INFORMATION

Acetaminophen Tylenol®, PediaCare® Fever Reducer/Pain Reliever, FeverAll®, Little Fevers®, Triaminic Fever Reducer®, Tempra®
  • Multiple strengths available
  • Given to children of all ages
  • Given every 4 hours
  • May be found in OTC cold/cough meds
Ibuprofen Motrin®, Advil®, PediaCare® Pain Reliever/Fever Reducer IB
  • Multiple strengths available
  • Given to children older than 6 months of age
  • Given every 6 to 8 hours

Because these medications use different active ingredients and mechanisms to treat symptoms, parents can use both acetaminophen and ibuprofen (alone or in combination) to safely treat their child’s fever and pain. Of note, aspirin should not be used in children (less than 16 years of age) with viral illnesses due to an association with Reye’s syndrome, a serious and potentially life-threatening illness. Additionally, although acetaminophen can safely be used in infants and children of all ages, fever-reducing medications should not be given to babies less than 2 months of age prior to speaking with a pediatrician or healthcare provider. For more information on fever and its causes and treatment, visit here. Allergies:  Children with allergic symptoms, such as an itchy/runny nose, sneezing/sniffling, or watery/pink eyes, may need to take a daily medication to help reduce their symptoms.  Diphenhydramine, loratadine, cetirizine, and fexofenadine are all common antihistamines, or medications which block histamine from causing allergic symptoms. As shown in the table, many of the generic, allergy medications have several different brand names:

OVER-THE-COUNTER ALLERGIC MEDICATIONS:

ACTIVE INGREDIENT

BRAND NAME

EXTRA INFORMATION

Diphenhydramine Benadryl®
  • Causes drowsiness
  • May be found in OTC cold/cough meds
  • Given every 4 to 6 hours
Loratadine Claritin®, Alavert®, Allergy Relief for Kids®
  • Given once a day
Cetirizine Zyrtec®, All Day Allergy Children’s®
  • Given once or twice a day
Fexofenadine Allegra®
  • Given once or twice a day

Diphenhydramine is a quick-acting antihistamine that requires more frequent dosing and is typically used to treat shorter-acting symptoms, such as hives, itchiness, or severe allergic reactions. Additionally, because it causes drowsiness, diphenhydramine is oftentimes found in many nighttime cold and cough medications. Loratadine, cetirizine, and fexofenadine, on the other hand, can be used for more persistent or chronic allergic symptoms since they’re longer acting and only given once or twice a day. Although they use different active ingredients to treat allergic symptoms, they all similarly block histamine and should not be used in combination unless advised by your pediatrician or healthcare provider!

Cold and Cough:  Triaminic®, Dimetapp®, PediaCare®, Robitussin®, Mucinex®, and Sudafed® are some of the most popular, over-the-counter cold and cough medications available today. Active ingredients, such as acetaminophen (fever reducer), brompheniramine (antihistamine), chlorpheniramine (antihistamine), diphenhydramine (antihistamine), phenylephrine (decongestant), dextromethorphan (cough suppressant), and guaifenesin (cough expectorant), either alone or in combination, are found in all of these brand-named medications.  The difference between each brand (and their multiple products) lies in the “recipe” of active ingredients found in each medication. For example, Dimetapp® Multi-Symptom Cold & Flu is composed of acetaminophen, chlorpheniramine, dextromethorphan, and phenylephrine, whereas Mucinex® Multi-Symptom Cold is made up of dextromethorphan, guaifenesin, and phenylephrine.

OVER-THE-COUTNER COLD AND COUGH MEDICATIONS:

ACTIVE INGREDIENT(S)

BRAND NAME

Acetaminophen, Dextromethorphan, Chlorpheniramine, Phenylephrine Dimetapp® Multisystem Cold & Flu; PediaCare® Multi-Symptom Cold; PediaCare® Flu
Dextromethorphan, Guaifenesin, Phenylephrine Mucinex® Multi-Symptom Cold; Mucinex® Congestion & Cough; Children’s Robitussin® Cough & Cold CF
Diphenhydramine, Phenylephrine Dimetapp® Nighttime Cold & Congestion; Triaminic® Night Time Cold & Cough; PediaCare® Nighttime Multi-Symptom Cold
Chlorpheniramine, Dextromethorphan Dimetapp® Long-Acting Cough Plus Cold; Vicks® Children’s Nyquil; Children’s Robitussin® Cough & Cold Long-Acting
Phenylephrine, Dextromethorphan Triaminic® Daytime Cold & Cough;  Sudafed® PE Cold & Cough; PediaCare® Daytime Multi-Symptom Cold

It’s important to remember that over-the-counter cold and cough medications should NOT be used to treat infants and children less than 6 years of age. Research does not support or show that these medications provide any symptomatic relief or improvement in younger children, and have been associated with serious and potentially life-threatening side effects related to their use. Alternative medications and products, such as normal saline (salt water) sprays, suction bulbs/syringes/aspirators, and cool mist humidifiers, can all be safely used in young children.

If chosen and used appropriately, common, childhood symptoms and illnesses can be safely treated with over-the-counter medications. However, if your child has a chronic, medical illness or severe and persistent symptoms, you should always speak with your pediatrician or subspecialty doctor prior to starting any new medications. If your child accidentally takes too much medication or the wrong medication, call the Poison Control Hotline at 1-800-222-1222, but if he/she becomes unresponsive, stops breathing and turns blue, develops seizure-like activity, or appears very ill, call 911 and seek medical care immediately.

Can I take allergy medicine with Advil?

Interactions between your drugs No interactions were found between Allergy Relief D 24 Hour and ibuprofen. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Can you take Claritin and Advil at same time?

Interactions between your drugs No interactions were found between Advil and Claritin.

What medications should not be taken with Advil?

Some products that may interact with this drug include: aliskiren, ACE inhibitors (such as captopril, lisinopril), angiotensin II receptor blockers (such as losartan, valsartan), cidofovir, corticosteroids (such as prednisone), lithium, "water pills" (diuretics such as furosemide).

Can you take Advil or Tylenol with allergy medicine?

No interactions were found between ibuprofen and Tylenol Allergy Multi-Symptom. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.