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How Much Vitamin D is Too Much? A Case Report and Review of the LiteratureSara De Vincentis et al. Endocr Metab Immune Disord Drug Targets. 2021. Free PMC article AbstractBackground: The beneficial effects of vitamin D, together with the high prevalence of vitamin D deficiency, have led to an expanding use of vitamin D analogues. While inappropriate consumption is a recognized cause of harm, the determination of doses at which vitamin D becomes toxic remains elusive. Case presentation: A 56-year woman was admitted to our Hospital following a 3-week history of nausea, vomiting, and muscle weakness. The patient had been assuming a very high dose of cholecalciferol for 20 months (cumulative 78,000,000UI, mean daily 130,000UI), as indicated by a non-- conventional protocol for multiple sclerosis. Before starting vitamin D integration, serum calcium and phosphorus levels were normal, while 25OH-vitamin D levels were very low (12.25 nmol/L). On admission, hypercalcemia (3.23 mmol/L) and acute kidney injury (eGFR 20 mL/min) were detected, associated with high concentrations of 25OH-vitamin D (920 nmol/L), confirming the suspicion of vitamin D intoxication. Vitamin D integration was stopped, and in a week, hypercalcemia normalized. It took about 6 months for renal function and 18 months for vitamin D values to go back to normal. Conclusion: This case confirms that vitamin D intoxication is possible, albeit with a high dose. The doses used in clinical practice are far lower than these and, therefore, intoxication rarely occurs even in those individuals whose baseline vitamin D serum levels have never been assessed. Repeated measurements of vitamin D are not necessary for patients under standard integrative therapy. However, patients and clinicians should be aware of the potential dangers of vitamin D overdose. Keywords: Vitamin D; cholecalciferol; hypercalcemia.; intoxication; overdose; toxicity. Copyright© Bentham Science Publishers; For any queries, please email at . Figures
 Temporal evolution of serum vitamin D (A), creatinine (B), PTH (C), serum calcium (D), and Calcium to Phosphorus ratio (E) during the ultra-high dose supplementation of cholecalciferol (grey area) ended at the moment of clinical intoxication, and during the subsequent follow-up. Grey area from January 2015 to September 2016 defines the period of supplementation with high doses of vitamin D. In box A: levels of vitamin D from March 2015 to September 2016 are above 375 nmol/L, but not assessed through dilution, and they are represented by the red dashed line. In boxes B, D and E: horizontal dashed lines represent the upper limit of normal ranges of creatinine, calcium, and Ca/P ratio. In box C: horizontal dashed lines represent the upper and the lower limits of normal range of PTH. Abbreviations: Ca, calcium; P, phosphorus; PTH, parathyroid hormone. (A higher resolution / colour version of this figure is available in the electronic copy of the article). Flow-chart of the literature review. Similar articles
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How much vitamin D is too much?The safe upper limit of intake is set at 4,000 IU per day. Intake in the range of 40,000–100,000 IU per day (10–25 times the recommended upper limit) has been linked with toxicity in humans.
Can I take 5000 IU of vitamin D3 daily?In summary, long-term supplementation with vitamin D3 in doses ranging from 5000 to 50,000 IUs/day appears to be safe.
How much vitamin D can I take a day?The recommended daily amount of vitamin D is 400 international units (IU) for children up to age 12 months, 600 IU for people ages 1 to 70 years, and 800 IU for people over 70 years.
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Can you overdose on vitamin d supplements
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